As Casualty moves forward into 2025 and beyond, Holby’s ED is undergoing one of its most dramatic transformations yet. Legacy faces have departed, controversial newcomers have arrived, and a major shift in the series’ setting is already on the cards. Here’s a rundown of all the significant cast changes fans need to know.

🔹 Major New Arrivals

Indie Jankowski (Naomi Wakszlak)

One of the most talked-about new faces, Indie Jankowski joined Holby as a fresh paramedic graduate under pressure to prove herself. Her backstory involves a complicated relationship with her father, who becomes entangled in crime, forcing Indie to make tough choices.

Sean Redmond (Seth Somers)

A confident, assertive surgeon, Sean entered the ED with strong clashes already brewing — especially with Rash Masum. He also becomes housemates with Tariq Hussein, adding layers to hospital dynamics.

Flynn Byron (Olly Rix)

Perhaps the most high-profile addition, Flynn is the new Clinical Lead of the ED, introduced in the Internal Affairs arc. His arrival comes with personal turmoil — separation from his wife Claire and tension with his father-in-law, surgeon Russell Whitelaw.

Kareem Hussein (Ravin J. Ganatra)

Introduced as Tariq Hussein’s estranged father, Kareem’s arrival adds family secrets to the ED’s workload. His connection to Rash and hidden agendas bring intrigue.

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🔻 Major Departures & Exits

Rich Walker (Michael Keogh)

One of 2025’s first casualties, Rich Walker died in the wake of a disaster involving a plane crash. His heroic exit sent shockwaves through personal relationships, especially between Siobhan McKenzie and Stevie Nash.

Russell Whitelaw (Robert Bathurst)

His return was controversial from the start. Introduced as a brilliant but domineering surgeon, Russell’s storyline ended in scandal and exit after nurse Rida Amaan accused him of abuse. The character left with his reputation destroyed.

Though not a complete absence for all time, Tariq’s tenure in the ED ended mid-series. His departure, around episode 19 of Internal Affairs, left a void among the junior doctors.

Sophia’s exit occurred in episode 15 of Public Property. Her storyline proved emotionally taxing, and the departure marked one of the many internal shifts in 2025’s casting.

Ngozi Okoye (Adesuwa Oni)

Perhaps the most emotionally impactful exit of all — after her relapse, Ngozi ultimately died. Her death not only ended her journey but reshaped the ED, particularly affecting Nicole Piper and her son Obi.

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🔄 Bigger Changes Ahead

Location Shift to Wales

One of the boldest changes planned for Casualty will take effect after Series 39. BBC documents suggest that the show’s fictional setting will move from Holby to a hospital in Wales, reflecting real NHS settings there while maintaining the show’s essence.

Series 40 as the Final Holby-Based Series

Series 40 is expected to be the last fully set in Holby under the existing production contract. After this, the transition to a Welsh hospital setting may bring additional cast shakeups.

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✅ What Remains: Returning Cast & Core Continuity

Despite all the changes, several mainstays are staying on. The 2025 cast list for Series 39 and the upcoming Series 40 includes: Dylan Keogh, Jan Jenning, Jodie Whyte, Stevie Nash, Siobhan McKenzie, Faith Cadogan, Rash Masum, Nicole Piper, Iain Dean, Rida Amaan, and the new additions like Indie Jankowski and Flynn Byron.

These characters will anchor continuity amid the shakeups, bridging old relationships with new conflicts.